Journal article
Risks of primary extracolonic cancers following colorectal cancer in lynch syndrome
AK Win, NM Lindor, JP Young, FA MacRae, GP Young, E Williamson, S Parry, J Goldblatt, L Lipton, I Winship, B Leggett, KM Tucker, GG Giles, DD Buchanan, M Clendenning, C Rosty, J Arnold, A Joan Levine, RW Haile, S Gallinger Show all
Journal of the National Cancer Institute | OXFORD UNIV PRESS INC | Published : 2012
DOI: 10.1093/jnci/djs351
Abstract
Background Lynch syndrome is a highly penetrant cancer predisposition syndrome caused by germline mutations in DNA mismatch repair (MMR) genes. We estimated the risks of primary cancers other than colorectal cancer following a diagnosis of colorectal cancer in mutation carriers.MethodsWe obtained data from the Colon Cancer Family Registry for 764 carriers of an MMR gene mutation (316 MLH1, 357 MSH2, 49 MSH6, and 42 PMS2), who had a previous diagnosis of colorectal cancer. The KaplanMeier method was used to estimate their cumulative risk of cancers 10 and 20 years after colorectal cancer. We estimated the age-, sex-, country-and calendar periodspecific standardized incidence ratios (SIRs) of ..
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Grants
Awarded by National Cancer Institute
Funding Acknowledgements
National Cancer Institute, National Institutes of Health under RFA #CA-95-011, and through cooperative agreements with members of the Colon Cancer Family Registry and Principal Investigators. AKW is supported by the Picchi Brothers Foundation Cancer Council Victoria Cancer Research Scholarship, Australia. JLH is a National Health and Medical Research Council Australia Fellow. MAJ is a National Health and Medical Research Council Senior Research Fellow. JPY is a Cancer Council Queensland Senior Research Fellow. CR is a Jass Pathology Fellow.